Formulation Development and Evaluation of Floating Tablets of Zolmitriptan

Zolmitriptan is the antimigraine agent widely used for treatment of migraine. It shows half-life 2.5 – 3 h which indicate frequent dosing to achieve proper pharmacological action drug. Gastro Retentive Drug Delivery System (GRDDS) a common approach decrease frequency and increase patient compliance, delivery drug through such an floating tablet formulation will meet requirement. This system showed substantial effect on release swelling properties. The tablets were formulated by using direct compression technique along with hydrophilic polymers gas generating system. In preliminary trials, we observed that within pharmacopeial limit. % formulations (F1 F9) was studied up 6 it found from 52 91 %. cumulative percentage inversely proportional polymer concentrations HPMC K100 M PVP K 30. batches follow Higuchi model involves diffusion mechanism. In-vitro dissolution studies good percent release, in accordance robinson-errikson equation. Good buoyancy additional h, trailed diffusion.